BIOMETRIC NEURO-OPTIC TECHNOLOGY

Download PupilMetrics for Android

or

Download PupilMetics for Windows

Mission Statement

The Clinical Neuro-Optic Research Initiative (CNRI) advances the science of pupil-based neurodiagnostics by preserving historic clinical insights, developing modern analytic tools, and conducting rigorous research that explores the relationship between ocular micro-structures and systemic health. Our mission is to validate and expand neuro-optic biomarkers that can support future breakthroughs in early detection, monitoring, and non-invasive assessment of autonomic and neurological function.

Vision

CNRI envisions a future in which standardized neuro-optic biomarkers complement mainstream clinical assessment, enabling earlier detection of health imbalances, more personalized care, and a deeper understanding of the body’s autonomic responses. We aim to become a trusted research institution that bridges historical clinical investigations with modern scientific rigor, ensuring that decades of prior work are not lost but elevated, validated, and expanded using contemporary technology.

Organization

Building on decades of pioneering clinical observations conducted in Russia and Korea during the 1980s–1990s, CNRI integrates modern imaging, pattern recognition, and data-driven methodologies to investigate how subtle pupil irregularities may reflect underlying autonomic and neurological function. CNRI conducts non-invasive human studies, develops analytic frameworks, and collaborates with international researchers to explore the emerging field of neuro-optic biomarkers.

LEARN MORE

Detection of Pupillary Parameters

Pupillary Parameters

Numerical data analysis of the iris and pupillary borders – The pupil tonus represented via the ventral and autonomic nervous system. Detection of pupillary ellipses – Total deformations are referred to as ellipses, resulting in the pupil assuming an oval shape. It is hypothesized that the origin of this phenomenon lies within the Central Nervous System and alterations in the Cerebrospinal fluid. When the pupil appears elliptical, it typically indicates a prior involvement of cranial nerves. Detection of pupillary deformations – Under normal conditions, pupils have a regular round shape with even edges. Several types of pupil deformations can be distinguished including Drawing (oval-elliptic forms), Local flatness (sector deformations, parasympathetic innervation), Local Protrusions (sector deformations, sympathetic innervation) and Multiformities.

Detection of collarette anomalies

The collarette’s circular conformity is a measure of nervous system equilibrium. It suggests a direct link between disturbances in the intestines and peripheral disturbances elsewhere in the body.

Constitutional Research

Constitutional classification system research derived from the pioneering and research efforts of Josef Deck, Helmut.W. Schimmel, Joaquim Broy, Theodore Kriege and Rudolf Schnabels’ original development work in Constitutional Classification Systems.

The Clinical Neuro-Optic Research Initiative (CNRI) advances pupil-based neurodiagnostics by preserving historical insights, developing modern analytic tools, and researching links between ocular microstructures and systemic health. Our mission is to validate and expand neuro-optic biomarkers for breakthroughs in early detection, monitoring, and non-invasive assessment of autonomic and neurological function.