Abstract
Objectives: Pupillary light reflex (PLR) parameters can be used as quantitative biomarkers of neurological function. Since digital infrared pupillometry is expensive, we sought to examine alterations in PLR parameters using a smartphone quantitative pupillometry platform in subjects with acute ischemic stroke (AIS).
Results: Healthy controls (n = 132) and AIS patients (n = 31) were enrolled. Significant differences were observed in PLR parameters for healthy subjects when compared to pre-thrombectomy subjects in both mean and absolute inter-eye differences after post hoc Bonferroni correction. The proprietary NPi score was not significantly different for all groups and comparisons.
Conclusions: Significant alterations in the PLR were observed in AIS patients with LVO before thrombectomy, indicating the potential use of smartphone pupillometry for detection of LVO.
Authors: Anthony J Maxin 1 , Bernice G Gulek 2 , John Chae 3 , Graham Winston 3 , Philine Weisbeek 4 , Lynn B McGrath 3 , Michael R Levitt 5
PMID: 37857150 DOI: 10.1016/j.jstrokecerebrovasdis.2023.107430
Abstract link: https://pubmed.ncbi.nlm.nih.gov/37857150/
