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Clinical Neuro-Optic Reseach Initiative
  • Home
  • Human Eye Project
    • The Pupil
    • Pupil Decentration-Multiformaties
    • Pupil Deformations
    • Pupil Color and Dimensions
    • Pupil Anisocoria
    • Pupil Miosis
    • Pupil Mydriasis
    • Pupil Reflexes
    • The Collarette
    • The Iris
  • PupilMetrics App
    • PupilMetrics Android
    • PupilMetrics Windows
    • PupilMetrics Mac OS
  • Documentation
  • Pricing
  • Learn More
    • CNRI Research
    • History
    • About
    • Eye Photo Tips & Tricks
    • IRB Status
    • Pupil Abstract Blog
    • Privacy Policy
    • Terms of Service

Getting Started

5
  • 1.1 System Requirements
  • 1.2 Installation
  • 1.3 Licensing
  • 1.4 First Launch
  • 1.5 Desktop Window & Keyboard Shortcuts

Capturing Eye Images

8
  • 2. Capturing Eye Images
  • 2.1 Camera Source Selection
  • 2.2 Quality-Gated Camera Mode – Android App
  • 2.3 Manual Camera Mode – Android
  • 2.4 USB / UVC Iriscope (Dino-Lite)
  • 2.5 PLR Video Mode – Android
  • 2.6 Import from Gallery
  • 2.7 Tips for a Good Capture

Reading the Analysis Results

10
  • 3. Reading the Analysis Results
  • 3.1 The Iris Zone Map
  • 3.2 PI Ratio (Pupil–Iris Ratio)
  • 3.3 Zone Findings — Flattenings (FLAT) and Protrusions (PROT)
  • 3.4 ANW Assessment (Collarette / Autonomic Nerve Wreath)
  • 3.5 Decentration (Pupil Position)
  • 3.6 Ellipseness (Pupil Shape)
  • 3.7 Anisocoria (Pupil Size Difference)
  • 3.8 Confidence Scores & Hybrid Fusion
  • 3.9 Scan History

Patient Management

4
  • 4. Patient Management & Exports
  • 4.1 PDF Report
  • 4.2 Plain-Text & JSON Export
  • 4.3 Sharing & Filing

Natural Medicine Therapy Panels

8
  • 5. Natural Medicine Therapy Panels
  • 5.1 Enabling the Therapy Modules
  • 5.2 How Zone Findings Drive the Therapy Panels
  • 5.3 Herbal Recommendations Panel
  • 5.4 Nutrition Recommendations Panel
  • 5.5 Chiropractic Correlations Panel
  • 5.6 TCM Correlations Panel
  • 5.7 Reading Therapy Panels Together

Constitutional Iridology

7
  • 6. Constitutional Iridology
  • 6.1 Background & Theoretical Basis
  • 6.2 The 34 Constitutional Types
  • 6.3 Selecting a Constitutional Type
  • 6.4 Constitutional Panel in Analysis Results
  • 6.5 Constitutional Section in the PDF Report
  • 6.6 Clinical Guidance & Limitations

Exporting PDF Reports

2
  • 7. Exporting PDF Reports
  • 7.1 Regenerating a PDF

Settings & Customization

5
  • 8. Settings & Customization
  • 8.1 Languages
  • 8.2 Zone Overlay & Observer Notes
  • 8.3 ML Comparison Panel
  • 8.4 About & Support

Clinical & Legal Disclaimers

2
  • 9. Clinical & Legal Disclaimers
  • 9.1 Data Privacy
View Categories
  • Home
  • PupilMetrics Documentation
  • Getting Started
  • 1.2 Installation

1.2 Installation

1 min read

**Windows Desktop**

1. Run the PupilMetrics installer (`PupilMetrics_Setup.exe`). PupilMetrics can either be downloaded from our website (newest features always released first on our website: PupilMetrics Windows

PupilMetrics can also be downloaded from the Microsoft store: https://apps.microsoft.com/detail/9nl4s313hj8t

2. The installer places the application in `Program Files\PupilMetrics` and creates a desktop shortcut.

3. If using a Dino-Lite iriscope, ensure the **DNVideoX** driver is installed before launching (see Section 2.5). This will allow you to use the iriscope microtouch feature built into iriscope.

**Android**

Install from the Google Play Store or load the provided APK.

**iOS**

Install MAC PC version directly from this website: PupilMetrics MAC OS

MAC users, please note: Because this software is distributed directly from our website (and not through the Mac App Store), macOS may show a security warning during installation. This is completely normal.

Apple includes these warnings as part of its Gatekeeper security system to protect users from unknown or unverified applications. Why You’re Seeing a Warning

When you try to open the app for the first time, you may see a message like:

“This app can’t be opened because it is from an unidentified developer.”

This does not mean the app is unsafe, it simply means Apple has not reviewed or notarized it through their App Store process.

How to Open the App (2 Easy Methods) #

Method 1 — Right-Click Open (Recommended) #

  1. Locate the downloaded app file (usually in your Downloads folder)
  2. Right-click (or Control + click) the app
  3. Click Open
  4. A warning will appear again — click Open one more time
  5. This permanently allows your Mac to trust the app.

Method 2 — System Settings Override #

If you already tried opening and got blocked:

  1. Open System Settings
  2. Go to Privacy & Security
  3. Scroll down to the Security section
  4. You’ll see a message about the blocked app
  5. Click “Open Anyway”
  6. Confirm when prompted

🔐 Important Notes #

  • This process only needs to be done once
  • Future launches will open normally
  • The app does not require disabling system security features
  • No special permissions are needed beyond standard macOS behavior

💡 Extra Tip (If App Won’t Launch) #

If macOS still refuses to open the app:

  • Make sure the file is fully downloaded (not partially)
  • Try moving the app into your Applications folder before opening
  • Ensure your macOS version meets the minimum requirements

🧠 Why This Happens (Simple Explanation) #

Apple restricts apps that:

  • Are not from the App Store
  • Are not signed with an Apple Developer ID

This is a blanket policy — it applies to all independent software, including many trusted tools.

👍 Reassurance #

Thousands of legitimate Mac apps are distributed this way. These warnings are a standard part of macOS and not an indication of a problem with the software.

Updated on March 24, 2026

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1.1 System Requirements1.3 Licensing
Table of Contents
  • How to Open the App (2 Easy Methods)
    • Method 1 — Right-Click Open (Recommended)
    • Method 2 — System Settings Override
  • 🔐 Important Notes
  • 💡 Extra Tip (If App Won’t Launch)
  • 🧠 Why This Happens (Simple Explanation)
  • 👍 Reassurance

The Clinical Neuro-Optic Research Initiative (CNRI) advances pupil-based neurodiagnostics by preserving historical insights, developing modern analytic tools, and researching links between ocular microstructures and systemic health. Our mission is to validate and expand neuro-optic biomarkers for breakthroughs in early detection, monitoring, and non-invasive assessment of autonomic and neurological function.

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