All tools added in Version 6.1+ extend — and are subject to — every disclaimer in the existing Section 9. In addition, the following research-only notices apply specifically to the advanced toolkit:
**Texture analysis tools (Gabor, LBP, GLCM, Frangi).** The texture metrics are computed from pixel intensity and image gradient information. They are influenced by capture lighting, white balance, and camera characteristics. Values should be interpreted longitudinally within the same patient and same device; cross-device and cross-practitioner comparisons require calibration that is not performed by PupilMetrics.
**Automatic detection tools (crypts, contraction furrows, heterochromia sectors).** Automatic detections are algorithmic suggestions, not clinical findings. Every detection should be visually verified by the trained practitioner. Detections falling below the reported confidence threshold are particularly prone to false positives from specular reflection, eyelash shadow, or image noise, even after specular inpainting is applied.
**Iris signature & session verification.** The iris-signature matching system is an internal record-linkage aid only. It is not a biometric identification system. It must not be used for identity verification, access control, security, forensic, or any regulatory purpose. Signatures are stored locally on the device; they are never transmitted and cannot be exported.
**PLR signal analysis.** Constriction kinetics, redilation time, hippus, and spectral parameters are experimental research metrics. Reference ranges are derived from published pupillometry literature using laboratory-grade equipment; mobile-camera PLR captures may produce systematic offsets from those ranges. Absolute values must not be used for clinical decision-making; within-patient longitudinal comparison is the intended use case.
**Intellectual property.** The Gabor, LBP, Frangi, GLCM, and SSIM algorithms are public-domain mathematical methods. The specific parameterisation, clinical interpretation mapping (Fibre Density → constitutional type, LBP histogram → lymphatic/haematogenic classification, etc.), and the iris signature implementation are proprietary to CNRI and © 2024–2026 PupilMetrics Research.
9.2 Research-Only Disclaimers for Advanced Features
1 min read
Updated on April 22, 2026
The Clinical Neuro-Optic Research Initiative (CNRI) advances pupil-based neurodiagnostics by preserving historical insights, developing modern analytic tools, and researching links between ocular microstructures and systemic health. Our mission is to validate and expand neuro-optic biomarkers for breakthroughs in early detection, monitoring, and non-invasive assessment of autonomic and neurological function.
